Sylvia Mangani | Medical Discoveries | Best Researcher Award

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Ms. Sylvia Mangani | Medical Discoveries | Best Researcher Award

Ms. Sylvia Mangani | University of Patras | Greece

Sylvia Mangani is a biochemist–biotechnologist and PhD candidate in Biochemistry at the University of Patras, whose research centers on cancer biology, particularly the influence of the extracellular matrix on tumor growth and regulation through 3D cell culture systems. Her academic journey combines strong foundations in biochemistry and biotechnology (BSc, MSc) with advanced experimental and analytical expertise. Her work integrates a broad range of molecular and cellular biology techniques, including quantitative PCR, Western blotting, immunofluorescence, functional assays, and RNA sequencing, complemented by bioinformatics analysis for gene expression and signaling pathway interpretation. Her research has significantly contributed to understanding how 3D cellular microenvironments influence cancer progression, focusing on breast cancer models. She has authored 12 peer-reviewed publications in recognized international journals, with her work cited over 55 times according to Google Scholar, reflecting growing recognition within the scientific community. Her contributions have also supported award-winning synthetic biology initiatives under the iGEM program and have been presented at national and international scientific conferences. She has established productive collaborations with prominent research institutions in Greece and abroad. Notably, she completed a funded Erasmus+ research placement at the University Hospital of Münster, Germany, under the supervision of Prof. Martin Götte, where she engaged in experimental oncology projects exploring cancer cell behavior and matrix interactions. She has also collaborated with the National and Kapodistrian University of Athens on biochemical and molecular analyses within the Laboratory of Biochemistry, Biotechnology, and Molecular Analysis. A member of the Hellenic Society of Biochemistry and Molecular Biology (HSBMB), she actively contributes to the advancement of biochemical and cancer research in Greece and Europe. Her ongoing studies aim to deepen the understanding of tumor–matrix dynamics in breast cancer, offering new insights for therapeutic innovation and cancer model development, positioning her among emerging researchers in molecular oncology.

Profiles: Orcid | Google Scholar | LinkedIn | Research Gate

Featured Publications 

Mangani, S., Piperigkou, Z., Mangani, S., Koletsis, N. E., Koutsakis, C., Mastronikolis, N. S., Franchi, M., & Karamanos, N. K. (2025, August). Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments. The FEBS Journal. https://doi.org/10.1111/febs.70207

Mangani, S., Vetoulas, M., Mineschou, K., Spanopoulos, K., Vivanco, M. d. M., Piperigkou, Z., & Karamanos, N. K. (2025, July 15). Design and applications of extracellular matrix scaffolds in tissue engineering and regeneration. Cells, 14(14), 1076. https://doi.org/10.3390/cells14141076

Franchi, M., Masola, V., Onisto, M., Franchi, L., Mangani, S., Zolota, V., Piperigkou, Z., & Karamanos, N. K. (2025, July 7). Ultrastructural changes of the peri-tumoral collagen fibers and fibrils array in different stages of mammary cancer progression. Cells, 14(13), 1037. https://doi.org/10.3390/cells14131037

Karamanos, N. K., Piperigkou, Z., Gourdoupi, C., Mangani, S., & Vivanco, M. d. M. (2025, June 1). Extracellular matrix matters: Matrix-based bioscaffolds in advancing translational cancer research and targeted therapy. American Journal of Physiology-Cell Physiology, 328(6), C1235–C1251. https://doi.org/10.1152/ajpcell.00050.2025

Ciampelli, C., Mangani, S., Nieddu, G., Formato, M., Ioannou, P., Kremmydas, S., Karamanos, N., & Lepedda, A. J. (2025, March). Effects of acidic polysaccharide-enriched extracts from Holothuria tubulosa on two- and three-dimensional invasive breast cancer cell models. Biology, 14(4), 334. https://doi.org/10.3390/biology14040334

Mangani, S., Kremmydas, S., & Karamanos, N. K. (2025, March). Mimicking the complexity of solid tumors: How spheroids could advance cancer preclinical transformative approaches. Cancers, 17(7), 1161. https://doi.org/10.3390/cancers17071161

Jean-louis Vigneresse | Research Excellence | Excellence in Research

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Prof. Jean-louis Vigneresse | Research Excellence | Excellence in Research

Prof. Jean-louis Vigneresse | université de lorraine | France

Jean-Louis Vigneresse is a distinguished French geophysicist known for his pioneering research on granite emplacement, crustal deformation, and thermal modeling. With decades of academic and international experience, he has contributed significantly to understanding Earth’s structural dynamics. He played key roles in major geoscientific programs like ECORS and Géofrance 3D and collaborated globally across Europe, the Americas, and Asia. As a professor and scientific leader, he has mentored numerous students and developed innovative geophysical tools. His research has been widely published and cited in top-tier journals. He also held administrative roles, promoting education and international cooperation. His career blends theoretical insight with practical application. Vigneresse’s legacy continues to shape modern geosciences.

Academic Profile 

Google Scholar | Orcid

Education

Jean-Louis Vigneresse holds a strong academic background in geophysics and earth sciences, having pursued advanced studies in engineering, structural geology, and geophysical modeling. He began his academic journey with training in geophysics at a premier French institute, focusing on magnetic anomalies and structural interpretations. His early research dealt with aeromagnetic and gravimetric analysis of volcanic and granitic terrains, reflecting a foundation in both applied and theoretical geophysics. His academic progression led him to conduct in-depth doctoral research on the modeling of granitic massifs and their deformation, integrating geophysical data with structural geological concepts. Further studies deepened his understanding of crustal processes, culminating in a high-level dissertation exploring the emplacement of granitic plutons under regional tectonic constraints.

Experience

Vigneresse has extensive experience in academia, research, and international collaboration. He has held teaching and research positions in several French universities, culminating in a senior academic post at a leading geological school. In addition to his teaching and research duties, he took on multiple administrative roles, including academic program development, student supervision, and coordination of international partnerships. He contributed to the modernization of geoscience curricula, particularly in petroleum geology and structural analysis. He has also been instrumental in developing applied geophysical tools, modeling software, and training programs that bridge academia and industry. His global engagement includes cooperative projects with universities and research centers across Europe, the Americas, Asia, and North Africa.

Research Interests

His research spans a broad range of topics in geophysics, structural geology, petrology, and crustal dynamics. His work has addressed granite emplacement mechanisms, partial melting, melt migration, deformation modeling, and the thermal evolution of the Earth’s crust. He has a particular interest in the links between tectonics, magmatism, and ore deposit formation. He developed physical and numerical models to simulate crustal processes and contributed to major geoscientific initiatives. His studies are well recognized for providing insights into the thermomechanical behavior of the crust and the geodynamic settings of granite-related phenomena.

Awards and Recognition

Jean-Louis Vigneresse is internationally recognized for his scholarly contributions, scientific collaborations, and educational leadership. He has published numerous research articles in prestigious international journals and has contributed as a reviewer and advisor to several scientific publications. His work has had significant influence in both academic and applied geoscience fields. He has been invited as a guest professor and scientific advisor in multiple countries and has played a key role in European scientific programs. His distinction lies in his ability to combine theoretical research with practical applications and international cooperation.

Publications


Granite magma formation, transport and emplacement in the Earth’s crust.

Author: Petford, N., Cruden, A. R., McCaffrey, K. J. W., & Vigneresse, J.-L.
Journal; Nature,(2000)

Nb-Ta fractionation in peraluminous granites: A marker of the magmatic-hydrothermal transition.

Author: Ballouard, C., Poujol, M., Boulvais, P., Branquet, Y., Tartèse, R., & Vigneresse, J.-L.
Journal; Geology, (2016)

Rheological transitions during partial melting and crystallization with application to felsic magma segregation and transfer.

Author: Vigneresse, J.-L., Barbey, P., & Cuney, M.
Journal: Petrology,  (1996)

Transpressional kinematics and magmatic arcs.

Author: Blanquat, M. D. S., Tikoff, B., Teyssier, C., & Vigneresse, J.-L.
Journal: Geological Society, London, Special Publications, (1998)

The Mortagne granite pluton (France) emplaced by pull-apart along a shear zone: Structural and gravimetric arguments and regional implication.

Author: Guineberteau, B., Bouchez, J.-L., & Vigneresse, J.-L.
Journal: Geological Society of America Bulletin, (1987)

Conclusion

The Research Excellence Award stands as a prestigious recognition of intellectual brilliance, innovation, and impactful contribution across scientific, academic, and interdisciplinary domains. It not only honors individual achievement but also promotes a culture of inquiry, collaboration, and societal relevance. By celebrating researchers who push boundaries and solve real-world problems, the award contributes to the global advancement of knowledge and inspires the next generation of scholars and innovators. This is more than an accolade — it is a platform for leadership, visibility, and lasting influence in the world of research.