Ms. Sylvia Mangani | University of Patras | Greece
Sylvia Mangani is a biochemist–biotechnologist and PhD candidate in Biochemistry at the University of Patras, whose research centers on cancer biology, particularly the influence of the extracellular matrix on tumor growth and regulation through 3D cell culture systems. Her academic journey combines strong foundations in biochemistry and biotechnology (BSc, MSc) with advanced experimental and analytical expertise. Her work integrates a broad range of molecular and cellular biology techniques, including quantitative PCR, Western blotting, immunofluorescence, functional assays, and RNA sequencing, complemented by bioinformatics analysis for gene expression and signaling pathway interpretation. Her research has significantly contributed to understanding how 3D cellular microenvironments influence cancer progression, focusing on breast cancer models. She has authored 12 peer-reviewed publications in recognized international journals, with her work cited over 55 times according to Google Scholar, reflecting growing recognition within the scientific community. Her contributions have also supported award-winning synthetic biology initiatives under the iGEM program and have been presented at national and international scientific conferences. She has established productive collaborations with prominent research institutions in Greece and abroad. Notably, she completed a funded Erasmus+ research placement at the University Hospital of Münster, Germany, under the supervision of Prof. Martin Götte, where she engaged in experimental oncology projects exploring cancer cell behavior and matrix interactions. She has also collaborated with the National and Kapodistrian University of Athens on biochemical and molecular analyses within the Laboratory of Biochemistry, Biotechnology, and Molecular Analysis. A member of the Hellenic Society of Biochemistry and Molecular Biology (HSBMB), she actively contributes to the advancement of biochemical and cancer research in Greece and Europe. Her ongoing studies aim to deepen the understanding of tumor–matrix dynamics in breast cancer, offering new insights for therapeutic innovation and cancer model development, positioning her among emerging researchers in molecular oncology.
Profiles: Orcid | Google Scholar | LinkedIn | Research Gate
Featured Publications
Mangani, S., Piperigkou, Z., Mangani, S., Koletsis, N. E., Koutsakis, C., Mastronikolis, N. S., Franchi, M., & Karamanos, N. K. (2025, August). Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments. The FEBS Journal. https://doi.org/10.1111/febs.70207
Mangani, S., Vetoulas, M., Mineschou, K., Spanopoulos, K., Vivanco, M. d. M., Piperigkou, Z., & Karamanos, N. K. (2025, July 15). Design and applications of extracellular matrix scaffolds in tissue engineering and regeneration. Cells, 14(14), 1076. https://doi.org/10.3390/cells14141076
Franchi, M., Masola, V., Onisto, M., Franchi, L., Mangani, S., Zolota, V., Piperigkou, Z., & Karamanos, N. K. (2025, July 7). Ultrastructural changes of the peri-tumoral collagen fibers and fibrils array in different stages of mammary cancer progression. Cells, 14(13), 1037. https://doi.org/10.3390/cells14131037
Karamanos, N. K., Piperigkou, Z., Gourdoupi, C., Mangani, S., & Vivanco, M. d. M. (2025, June 1). Extracellular matrix matters: Matrix-based bioscaffolds in advancing translational cancer research and targeted therapy. American Journal of Physiology-Cell Physiology, 328(6), C1235–C1251. https://doi.org/10.1152/ajpcell.00050.2025
Ciampelli, C., Mangani, S., Nieddu, G., Formato, M., Ioannou, P., Kremmydas, S., Karamanos, N., & Lepedda, A. J. (2025, March). Effects of acidic polysaccharide-enriched extracts from Holothuria tubulosa on two- and three-dimensional invasive breast cancer cell models. Biology, 14(4), 334. https://doi.org/10.3390/biology14040334
Mangani, S., Kremmydas, S., & Karamanos, N. K. (2025, March). Mimicking the complexity of solid tumors: How spheroids could advance cancer preclinical transformative approaches. Cancers, 17(7), 1161. https://doi.org/10.3390/cancers17071161