Sylvia Mangani | Medical Discoveries | Best Researcher Award

Published on by Scientist Day

Ms. Sylvia Mangani | Medical Discoveries | Best Researcher Award

Ms. Sylvia Mangani | University of Patras | Greece

Sylvia Mangani is a biochemist–biotechnologist and PhD candidate in Biochemistry at the University of Patras, whose research centers on cancer biology, particularly the influence of the extracellular matrix on tumor growth and regulation through 3D cell culture systems. Her academic journey combines strong foundations in biochemistry and biotechnology (BSc, MSc) with advanced experimental and analytical expertise. Her work integrates a broad range of molecular and cellular biology techniques, including quantitative PCR, Western blotting, immunofluorescence, functional assays, and RNA sequencing, complemented by bioinformatics analysis for gene expression and signaling pathway interpretation. Her research has significantly contributed to understanding how 3D cellular microenvironments influence cancer progression, focusing on breast cancer models. She has authored 12 peer-reviewed publications in recognized international journals, with her work cited over 55 times according to Google Scholar, reflecting growing recognition within the scientific community. Her contributions have also supported award-winning synthetic biology initiatives under the iGEM program and have been presented at national and international scientific conferences. She has established productive collaborations with prominent research institutions in Greece and abroad. Notably, she completed a funded Erasmus+ research placement at the University Hospital of Münster, Germany, under the supervision of Prof. Martin Götte, where she engaged in experimental oncology projects exploring cancer cell behavior and matrix interactions. She has also collaborated with the National and Kapodistrian University of Athens on biochemical and molecular analyses within the Laboratory of Biochemistry, Biotechnology, and Molecular Analysis. A member of the Hellenic Society of Biochemistry and Molecular Biology (HSBMB), she actively contributes to the advancement of biochemical and cancer research in Greece and Europe. Her ongoing studies aim to deepen the understanding of tumor–matrix dynamics in breast cancer, offering new insights for therapeutic innovation and cancer model development, positioning her among emerging researchers in molecular oncology.

Profiles: Orcid | Google Scholar | LinkedIn | Research Gate

Featured Publications 

Mangani, S., Piperigkou, Z., Mangani, S., Koletsis, N. E., Koutsakis, C., Mastronikolis, N. S., Franchi, M., & Karamanos, N. K. (2025, August). Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments. The FEBS Journal. https://doi.org/10.1111/febs.70207

Mangani, S., Vetoulas, M., Mineschou, K., Spanopoulos, K., Vivanco, M. d. M., Piperigkou, Z., & Karamanos, N. K. (2025, July 15). Design and applications of extracellular matrix scaffolds in tissue engineering and regeneration. Cells, 14(14), 1076. https://doi.org/10.3390/cells14141076

Franchi, M., Masola, V., Onisto, M., Franchi, L., Mangani, S., Zolota, V., Piperigkou, Z., & Karamanos, N. K. (2025, July 7). Ultrastructural changes of the peri-tumoral collagen fibers and fibrils array in different stages of mammary cancer progression. Cells, 14(13), 1037. https://doi.org/10.3390/cells14131037

Karamanos, N. K., Piperigkou, Z., Gourdoupi, C., Mangani, S., & Vivanco, M. d. M. (2025, June 1). Extracellular matrix matters: Matrix-based bioscaffolds in advancing translational cancer research and targeted therapy. American Journal of Physiology-Cell Physiology, 328(6), C1235–C1251. https://doi.org/10.1152/ajpcell.00050.2025

Ciampelli, C., Mangani, S., Nieddu, G., Formato, M., Ioannou, P., Kremmydas, S., Karamanos, N., & Lepedda, A. J. (2025, March). Effects of acidic polysaccharide-enriched extracts from Holothuria tubulosa on two- and three-dimensional invasive breast cancer cell models. Biology, 14(4), 334. https://doi.org/10.3390/biology14040334

Mangani, S., Kremmydas, S., & Karamanos, N. K. (2025, March). Mimicking the complexity of solid tumors: How spheroids could advance cancer preclinical transformative approaches. Cancers, 17(7), 1161. https://doi.org/10.3390/cancers17071161

Rosabel Camacho Gastélum | Scientific Breakthroughs | Women Researcher Award

Published on by Scientist Day

Dr. Rosabel Camacho Gastélum | Scientific Breakthroughs | Women Researcher Award 

Dr. Rosabel Camacho Gastélum, Centro Interdisciplinario de Ciencias Marinas, Mexico

Dr. Rosabel Camacho Gastélum is a researcher at the Centro Interdisciplinario de Ciencias Marinas , Mexico. Her work focuses on marine sciences, with a particular interest in the sustainable use and conservation of marine resources. She actively contributes to interdisciplinary research aimed at understanding and protecting ocean ecosystems.

Author Profile

Google Scholar

🎓Early Academic Pursuits

Rosabel Camacho Gastélum’s academic journey began with a strong foundation in biology, leading to her Bachelor’s degree in Biology with a specialization in Marine Biology. Her undergraduate thesis,  showcased her early interest in marine ecosystems. She furthered her education with a Master’s degree in Marine Resource Management, completing her thesis on “Identification of fish larvae from the family Sciaenidae in the Upper Gulf of California using molecular markers.” Currently, she is pursuing her PhD in Marine Sciences at Centro Interdisciplinario de Ciencias Marinas , Mexico.

🔬Professional Endeavors

Rosabel’s professional experience includes working as a Research Assistant on a vessel . During this tenure, she contributed to the collection of biological samples and physical data from the southern part and entrance of the Gulf of California. Her expertise in marine biology and research skills have been valuable assets in her professional endeavors.

📚Contributions and Research Focus

Rosabel has made significant contributions to the field of marine biology through her research and publications. Some notable publications include:

– Molecular identification and morphological description of Micropogonias megalops, Cynoscion othonopterus, C. reticulatus, and Menticirrhus in Mitochondrial DNA Part A (2017)
– Interannual variations of environmental factors and their effects on larval fish habitats in the Upper Gulf of California during early summer in Continental Shelf Research (2020)
– Horizontal and vertical distribution of fish larvae in the main entrance of Bahía de La Paz, Gulf of California (October 2022) in Continental Shelf Research (2025)

Her research focuses on marine species identification, ecology, and conservation, with a particular emphasis on the Gulf of California. Rosabel has also presented her research at conferences and science fairs, including a presentation on the genetic identification of fish larvae from the family Sciaenidae in the Upper Gulf of California.

📢Impact and Influence

Rosabel’s research has the potential to inform conservation efforts and management of marine resources in the Gulf of California. Her work on fish larvae identification and ecology can contribute to a better understanding of marine ecosystems and the impacts of environmental changes. By sharing her research with academic and general audiences, Rosabel is helping to advance the field of marine biology and promote awareness about the importance of marine conservation.

✍️Notable Publications

Horizontal and vertical distribution of fish larvae in the main entrance of Bahía de La Paz, Gulf of California (October 2022).

Author: R Camacho-Gastélum, L Sánchez-Velasco, SPA Jiménez-Rosenberg,

Journal: Continental Shelf Research, 105510

Year: 2025

Identificación de larvas de peces de la familia Sciaenidae del Alto Golfo de California, mediante marcadores moleculares.