Prof. Rolf Teschke | Klinikum Hanau | Germany
Rolf Teschke, M.D., Professor of Medicine, is a distinguished German physician and internationally recognized expert in gastroenterology, hepatology, and the complex mechanisms of hepatotoxicity. Born in Gera, he pursued medical studies at the universities of Munich and Marburg, earning his medical degree and completing his inaugural thesis. His early scientific foundation was shaped in pathology, where his interest in liver injury and toxic mechanisms first took root. A pivotal stage of his career unfolded in New York, where he worked under the mentorship of renowned liver specialist Charles S. Lieber. During this period, he conducted influential biochemical research on alcohol-related liver injury, including solubilizing and isolating the microsomal ethanol-oxidizing system and exploring cytochrome P450–related pathways. This work strengthened his commitment to uncovering the biological foundations of hepatotoxicity and decisively shaped his future research direction. Returning to Germany, Professor Teschke continued to advance academically in gastroenterology, hepatology, and infectious diseases at the Heinrich Heine University of Düsseldorf. He completed his habilitation, received a prestigious university research award, and expanded his clinical and experimental work on alcohol-induced liver damage, hydrocarbon toxicity, and the growing challenge of drug-induced liver injury. As a department director at a major teaching hospital, he further deepened his focus on drug-induced liver injury, contributing significantly to the development and refinement of the RUCAM causality assessment method in collaboration with international experts. His scholarly output is substantial, consisting of more than 250 English-language publications, including books and book chapters. His work has earned 6,890 citations across 4,042 documents, with an h-index of 48, reflecting his strong influence in the global hepatology community. He has served as associate editor of Annals of Hepatology and held editorial roles across numerous leading medical and scientific journals.
Profile; Scopus | Orcid | Research Gate
Featured Publications:
Teschke, R. Drug-Induced Autoimmune Hepatitis by Varenicline and Infliximab as a Continuous Disease Spectrum with Two Different Flares: Acute Liver Injury Followed by Hepatic Autoimmunity. Review.
Annotation: Discusses two-step autoimmune hepatitis triggered by pharmaceutical agents, highlighting diagnostic and clinical implications.
Teschke, R. Acute Liver Failure with Determinate rather than Indeterminate Etiology Facilitates Therapy and May Avoid Liver Transplantation: A Critical Analysis. Review.
Annotation: Evaluates clinical outcomes in acute liver failure and argues the benefits of precise etiological identification.
Teschke, R., et al. Drug-Induced Autoimmune Hepatitis: Robust Causality Assessment Using Two Different Validated and Scoring Diagnostic Algorithms. Review.
Annotation: Compares two validated diagnostic algorithms to strengthen causality assessment in drug-induced autoimmune hepatitis.
Teschke, R. Immunology Highlights of Four Major Idiosyncratic DILI Subtypes Verified by the RUCAM: A New Evidence-Based Classification. Review.
Annotation: Proposes an evidence-based immunological classification for idiosyncratic drug-induced liver injury (DILI).
Teschke, R., et al. Metabolic Mysteries of Copper Dysregulation in Wilson Disease. Review.
Annotation: Explores metabolic pathways and unresolved mechanisms underlying copper dysregulation in Wilson’s disease.
Teschke, R., et al. Open Questions on How Metabolic Dysfunction-Associated Steatotic Liver Disease Shapes the Course of Drug-Induced Liver Injury. Letter.
Annotation: Raises key unresolved scientific and clinical questions on the interaction between MASLD and DILI.